Oral health influences the general quality of life and poor oral health is linked to chronic conditions and systemic diseases. dental caries/plaque is an extremely prevalent infectious disease that has been shown to be associated with serious health problems. The objective of our study is to evaluate the antibacterial activity of ethanolic leaf extract of Arctostaphylos Uva ursi against selected cariogenic oral bacteria that causes dental plaque in fixed orthodontic appliances patients. Arctostaphylos Uva ursi is used medicinally since second century. the ethanolic extract of uva ursi leaf were used to find out the antibacterial potency against streptococcus mutans, streptococcus mitis streptococcus sanguis ,streptococcus salivarius, streptococcus sobrinus and Lactobacillus acidophilus. the extract exhibited significant antibacterial activity against streptococcus mitis, streptococcus mutans ,streptococcus sanguis __ampersandsignamp; streptococcus salivarius, streptococcus sobrinus with minimum bactericidal concentration of 1mg/ml and 5mg/ml respectively. whereas, the extract does not show antibacterial activity against Lactobacillus acidophilus.