Ferritin is a ubiquitous and highly conserved iron-binding protein. Increasingly, perturbations in cellular iron and Ferritin are emerging as an important element in the pathogenesis of disease. Ferritin levels seem to reflect the magnitude of iron stores in the body and decreased or increased serum Ferritin levels are used as a marker for anaemia and iron overload disorders. Serum Ferritin was discovered in the 1930s, and was developed as a clinical test in the 1970s. However, the presence of Ferritin in saliva was not documented until 1984. The salivary Ferritin values are usually higher than the iron stores present in the body and these values are subject to change in iron deficiency anaemia, iron overload disorders and protein malnutrition. The biological system maintains the salivary Ferritin levels at a higher level, probably for the iron dependent enzymatic functions of the saliva, thus conserving the iron through saliva. This paper gives an update of Ferritin and its presence in saliva and various mechanisms which cause a rise in Ferritin.