IJCRRI Journ Cur Res ReInternational Journal of Current Research and ReviewI Journ Cur Res Re2231-21960975-5241Radiance Research Academy1892General SciencesAN INVITRO STUDY OF CISPLATIN INDUCED NEPHROTOXICITY IN GOAT KIDNEY .SangeethaN119126This article is copyright of Popeye Publishing, 20092009This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.

Cisplatin (CP) is one of the most active cytotoxic agents in the treatment of cancer and has adverse side effects such as nephrotoxicity and hepatotoxicity. The present study was designed to determine the cisplatin induced nephrotoxicity by determining Urea, Creatinine, Malondialdehyde (MDA), reduced glutathione (GSH), Glutathione peroxidase (GPx), Superoxide dismutase (SOD) and Catalase (CAT) in goat kidney homogenates. A significantly (p__ampersandsignlt;0.02) increase in Urea and Creatinine was found. In addition, there was significant (p__ampersandsignlt;0.001) increase of MDA. But no significant difference in the non-enzymic antioxidant GSH in CP treated tissue homogenate but a less significant (p__ampersandsignlt;0.2) decrease in GPx and significant (p__ampersandsignlt;0.001) decrease in SOD and CAT was observed. Thus, excessive ROS production by CP causes an antioxidant imbalance which leads to lipid peroxidation and antioxidant depletion. In conclusion, CP treatment induces an irreversible kidney injury.

Cisplatin Nephrotoxicity Oxidative stress Antioxidant enzymes.