Introduction: Induced sputum is less invasive and economical procedure than bronchoscopy. A single induced sputum sample and bronchoscopy are very useful for diagnosing of Sputum smear-negative pulmonary tuberculosis (SSN-PTB). Our aim is to find out which procedure is better in diagnosis of sputum negative pulmonary tuberculosis. Methods: It is a cross-sectional prospective study in which consecutive patient were selected with possibly active pulmonary__ampersandsignnbsp; uberculosis, the diagnostic give way three induced sputum tests were weighed against with bronchoscopy. Patients whichever produced no sputum otherwise (acid fast) smear negative sputum. Bronchoscopy was only carried out if at least two induced sputum samples were smear negative. Results: Of 147 patients who completed all tests, 51 (34 %) had smear negative and culture positive specimens, 26 (51%) on bronchoscopy and 49 (96%) on induced sputum (p__ampersandsignlt;0.005). Two patients were culture positive on bronchoscopy alone compared with 25 patients on induced sputum alone; 24 were culture positive on both tests. Conclusions: Induced sputum test is better than bronchoscopy in diagnosis of sputum negative TB patients. Three induced sputum tests without bronchoscopy should carry out in patients examined for possibly active or inactive tuberculosis who produce no sputum or have smear negative sputum. Nosocomial tuberculosis may be a risk factor for Induced sputum testing so it is recommended it should be performed in respiratory isolation conditions