Background: The number patients with diabetic foot ulcers presenting to surgery clinics has been increasing at an alarming rate. Diabetic foot ulcers are the most common cause for nontraumatic foot amputation. This study was undertaken to analyze both the risk factors for development of foot ulcers in diabetics and for lower extremity amputation (LEA) in patients with diabetic foot ulcers. Methods: A prospective analytical study that assessed the various risk factors associated with the development of foot ulcers in diabetics and that eventually lead to LEA in these patients. Univariate analysis and multivariate logistic regression (WALD__ampersandsignlsquo;s TEST) were used to assess statistical significance. Results: A total of 120 patients were included in the study, of which 53 underwent LEA. The incidence of foot ulcers was found to be higher in the following categories: males, 5th decade, associated hypertension, hyperlipidemia, and duration of diabetes more than 5 years. The significant risk factors for LEA are male gender, smoking, alcohol consumption, duration of DM more than 5 years, ABPI__ampersandsignlt;0.9. Conclusion: Smoking, alcohol consumption, duration of diabetes__ampersandsigngt; 5 years, male gender and peripheral vascular diseases (ABPI__ampersandsignlt;0.9) are statistically significant risk factors for amputation of diabetic foot ulcer.