A clinical and pathologic study of 314 patients with uterine leiomyomas revealed no significant relationship between the presenting symptoms and degenerative changes in the tumors. Some form of degeneration was demonstrated in 44% of specimens. Correlation of symptomatology with the type of degenerative change showed that the hyaline change was the commonest type associated with each symptom or group of symptoms; whereas the other types of degeneration occurred at random. The commonest associated pathology contributing to symptomatology includes adenomyosis (39.22%), followed by follicular cyst in 24.11% of patients and endometrial hyperplasia in 57 cases.