Aim: In the last few decades, increased resistance of bacterial strains to drugs including antibiotics has been a major factor for increasing morbidity, mortality and healthcare costs to bacterial infections. With this concern, effort has been made to investigate the phytochemicals and antibacterial potency of chloroform, acetone, ethanol and aqueous extract from Chlorella vulgaris Beijerinck (Chlorellaceae). Method: Mass cultivation of algae was carried out in outdoor and chloroform, acetone, ethanol and aqueous extracts were extracted directly from the biomass. The extracts were subjected to phytochemical screening and antimicrobial activity against test organisms; E.coli, P.vulgaries, S.aureus, P.aeruginosa__ampersandsignnbsp;and B.subtilis by agar well diffusion assay and Minimum Inhibitory Concentration of all the four extracts were determined. Result: Phytochemical screening revealed the presence of alkaloid, flavonoid, phenol, tannin, terpenoids, saponin and glycosides. Acetone and ethanol extracts were potential antimicrobial agent when compared to chloroform and aqueous extracts. Aqueous extract showed very less inhibitory potency against test organisms. Conclusion: Daily supplementation of food with C. vulgaris Beijerinck will not only nourish in the body growth but it will also serve as immense source to defend against bacterial infection.