Background: Nerve Conduction Testing is frequently used by the physiotherapist as an investigation procedure for Carpal Tunnel Syndrome. Carpal Tunnel Syndrome may develop in Computer users as well as in General Population those who are using their wrist and finger frequently. Objectives: To compare the Nerve Conduction changes amongst the two groups of people; those working on computer and general__ampersandsignnbsp;population who are involved in cooking, masoning, sweeping etc. Methods: 60 individuals were divided into 2 groups, group A and group B consisting of 30 individuals each. Group A: Individuals without any symptoms of Carpal Tunnel Syndrome working for __ampersandsigngt; 4 hours per day for __ampersandsigngt; 1 year. Group B: Individuals belonging to general population not using computer. Analysis was based on the distal motor latency and sensory nerve action potential taken for the dominant hand. Results: Mean__ampersandsignplusmn;SD for Distal Motor Latency for GROUP A was 4.116__ampersandsignplusmn;0.265ms and for GROUP B was 3.243__ampersandsignplusmn;1.044ms. Mean__ampersandsignplusmn;SD for Digit II to Wrist latency for GROUP A was 2.845__ampersandsignplusmn;0.252ms and for GROUP B was 2.077__ampersandsignplusmn;0.556ms. Mean__ampersandsignplusmn;SD for Transcarpal to Wrist latency for GROUP A was 1.854__ampersandsignplusmn;0.289ms and for GROUP B was 1.414__ampersandsignplusmn;0.252ms. t__ampersandsignlsquo; calculated value for DML, Digit II to wrist and Transcarpal to wrist was 4.43, 6.88 and 6.27 respectively which was statistically significant as it is above the t__ampersandsignlsquo; tabulated value of 1.96. Conclusion: There is a significant difference in both the Groups for all the parameters. GROUP A individuals are having more chances for developing Carpal Tunnel Syndrome when compared to GROUP B individuals.