Background and Objective: Diabetes Mellitus is the most common endocrinal disorder worldwide. Long term uncontrolled diabetes is associated with complications of eyes, kidney, heart, blood vessels and nerves. Studies have been carried out to see the effect of diabetes on skeletal muscle strength but the results are conflicting; while very few studies have considered the muscle endurance. Moreover, the correlation of glycosylated haemoglobin levels (HbA1c) with handgrip strength (HGS) and hand grip endurance (HGE) has not been studied. So the present study was carried out in 100 type I diabetics and 164 type II diabetics to compare the HGS and HGE with 100 and 160 normal healthy non diabeticsubjects respectively. Also the objective of this study was to determine the relation of HbA1c with HGS and HGE. Research Methodology: HGS and HGE were measured using Handgrip dynamometer. HbA1c was assessed by cation - exchange resin method using Monozyme__ampersandsignlsquo;s Glycohemin kit on Transasia__ampersandsignlsquo;s semiautoanalyzer. Outcome of Study: Results of the study showed that type I __ampersandsignamp; II diabetics had significantly lower HGS than non diabetics. HGE was lower in type II diabetics while it was significantly higher in type I diabetics as compared to controls. This study also indicated that HGS and HGE had no significant correlation with HbA1c. Thus present study reveals that uncontrolled diabetics are at a risk of decreased muscle strength and endurance and the magnitude of affection is highly individual specific. Thus there is a need for development of strategies in the form of strict glucose control and resistant training exercise program to slow or prevent rapid decline in muscle function in diabetics.