Introduction: Autistic Spectrum Disorder (ASD) is spectrum of psychological condition, characterized by widespread abnormalities of social interaction and communication as well as severely restricted interests and highly repetitive behavior. Cognitive behavior therapy is effective in children with ASD. But data are lacking to prove efficacy of sensory integration therapy in treating the children with ASD. Method: An experimental study was carried out in the outpatient department of a physiotherapy college in Karnataka, India. 20 patients with Autistic Spectrum Disorder (ASD) were included in the study. They are randomly assigned into two groups. Group A: 10 (cognitive behavior therapy alone) and group B: 10 (sensory integration therapy and cognitive behavior therapy). The outcome measure used was Childhood Autism Rating Scale (CARS) and the study was conducted for Six months. Result: There was a significant decrease inCARS score (p__ampersandsignlt;0.001) in children with ASD who received Cognitive Behavior Therapy alone and combined therapies of Sensory Integration Therapy and Cognitive Behavior Therapy. Conclusion: Cognitive Behavior Therapy alone and combined therapies of Sensory Integration Therapy and Cognitive Behavior Therapy are effective in decreasing the symptom severity and maladaptive behaviors through CARS (Childhood Autism Rating Scale).