Objectives: Hypertension is the most common cardiovascular disease. Multiple regulatory mechanisms contribute to the evolution of hypertension. The change of cardio respiratory function in hypertension is associated with increase central sympathetic output to heart and skeletal muscles and peripheral resistance. Alternate nostril breathing (ANB) consists of slow deep breaths using one nostril at a time. ANB can produce different physiological responses and modulate cardio respiratory and autonomic function. Therefore the research was conducted to find out the effect of ANB on cardio respiratory functions. Methods: The responses of ANB on cardio respiratory function were investigated in 30 hypertensive subjects. The subjects performed ANB exercise (15min. every day in the morning) for four weeks. Cardio-respiratory parameters were recorded thrice; before ANB, after 15min. (acute exposure) and following 4 weeks of training of ANB. Results: Comparison of Mean arterial blood pressure (MABP), HR and RR responses were done using one __ampersandsignndash;way ANOVA. Multiple comparisons were performed using post- hoc analysis- Bonferroni test. The P- value set at 0.01 levels for all the statistical tests. There is significant decrease in Mean arterial blood pressure (MABP), heart rate (HR) and respiratory rate (RR) after ANB in hypertensive subjects. When compared to baseline value (p__ampersandsignlt;0.01). Conclusion: The study shows that the ANB has a significant effect on cardio respiratory function among hypertensive subjects. Therefore ANB exercise can be prescribed to hypertensive patients as an adjuvant to medical therapy.