Introduction: At colleges nationwide, large percentage of college students are feeling overwhelmed, sad, hopelessness and so depressed that they are unable to function well. It is seen that Anxiety disorders affect a lot to adults every year, and its levels among college students have been rising since long. The objective of the present study was to explore the severity of depression, anxiety and stress among undergraduate physiotherapy students. Methodology: 246 undergraduate physiotherapy students from one institute have been selected for the study purpose .Questionnaire based survey study was done. A DASS 21 questionnaire was given to the students and the aim of the study was explain to them. Duly completed forms were taken away for research study purpose. Result: Among all of total 246 students; Depression-145 were reported under normal category, 52 of them in mild, 35 in moderate level, 10 in severe category and 4 had fallen in the extremely severe category. The Anxiety scale reported 125 in normal, 34 in mild, 49 in moderate level, 20 in severe and 18 of them have been under extremely severe category. The study reported 159 normal cases for Stress scale, 35 were in mild, 31 in moderate, 20 in severe and 1 case in extremely severe score. Conclusion: Present study revealed maximum number of students in the normal category and some student__ampersandsignrsquo;s in raised level of anxiety and stress among undergraduate Physiotherapy students. Discussion: Consequently it is advised that the institute should take appropriate steps for reducing the level of depression and stress by undertaking counseling of the students and help them to cope up with their difficulties up to the institutional limit.