The present study was carried out to investigate the anti-rheumatic properties of methanolic extracts of the aerial parts of the plant Anisomeles malabarica R.Br., (Lamiaceae) using experimental animal models. The anti-rheumatic activity of the methanolic extracts was studied based on the effects on carrageenan-induced rat paw oedema. The preliminary phytochemicals were screened for the presence and absence of alkaloids, steroids, proteins, flavonoids, saponins, carbohydrates, tannins, fats and oils. The extracts in dose level 2000 mg/kg orally were used in anti-rheumatic studies. The methanolic extracts of leaves of Anisomeles malabarica R.Br., produced significant anti-rheumatic activity in a dosedependent manner (200 mg/Kg and 400 mg/Kg body weight) to that of standard drug indomethacin (10__ampersandsignnbsp;mg/Kg). The extract exhibited inhibitory effect in carrageenan induced hind paw oedema in rats with all the doses used when compared to the control group. The data obtained indicate that the crude extracts of the aerial parts of the plant Anisomeles malabarica R.Br., possess potential anti-rheumatic activity by supporting the folkloric usage of the plant to treat various inflammatory conditions.