Aim: To investigate the association of Homocysteine with lipid parameter and oxidative stress Methods: Population based cross sectional study included 60 coronary artery disease patients who visited Himalayan Institute of Medical Sciences during may 2008 to april 2009. Homocysteine and lipid profile was estimated by fully autoanalyzer, MDA level for oxidative stress was estimated by colorimetric technique on RA 50 Semi autoanalyzer. Statistical analysis: Pearson correlation and ?t test? from which p values were obtained. Results: Plasma level of Homocysteine and Malondialdehyde were significantly higher (p=0.000) in cases (CAD patients) than controls. Homocysteine shows significant positive correlation with Total Cholesterol, VLDA, LDL,Triglyceride and Malondialdehyde. Homocysteine shows negative but insignificant correlation with HDL. Conclusion: Levels of Homocysteine and Malondialdehyde obtained were found to be positively correlated with each other and with lipid parameters in this study. This indicates that Homocysteine enhances the oxidative stress by lipid peroxidation, which may be one of the cause for development of coronary artery disease.