FTIR spectroscopic techniques are widely used as a tool with unique capability and sensitivity. The shift and splitting up of the frequencies of molecular ions are interpreted in terms of molecular interactions. In the present investigation an attempt is made to correlate the spectroscopic results with thermodynamic study of L. Arginine mono hydrochloride in non-aqueous solutions. FTIR spectra of L. Arginine mono hydrochloride solutions and pure solvent are recorded. The observed vibrational spectra are analysed. Thermodynamic parameters such as internal pressure, free volume, Rao__ampersandsignrsquo;s constant, Wada__ampersandsignrsquo;s constant and adiabatic compressibility are measured. The results obtained from FTIR ananlysis are found to be in good agreement with the thermodynamic studies.