Volatile substance abuse and autoerotic behaviour are distinct phenomenon. Still considerable overlap is observed in some cases. Autoerotic deaths in transvestite are reported in young males, who tend to experiment alone and are heterosexual. We present a rare case of an autoerotic death involving a fatal combination of plastic bag asphyxia, and, intoxication with inhaled toluene whitener and alcohol. Of note in this case is the fact that the victim was a male with transvestite attire. Toluene and alcohol are known to have additive effects. Furthermore, toluene inhalation may induce cardiac arrhythmias, particularly aggravated by high sympathetic activity during autoerotic ritual. We discuss the death scene investigation, past use of lethal and nonlethal paraphilia, and, findings at autopsy in arriving at conclusion of accidental mode of death.