Objective __ampersandsignmdash; The aim of present study is to examine serum level of Selenium, Copper, Zinc and Iron in Liver cirrhosis patients and Compare the level of Selenium, Copper, Zinc and Iron in Patients with liver cirrhosis with age, sex matched normal control subjects. Research Design Methods__ampersandsignmdash; this open-ended comparative transverse study was designed to evaluate serum selenium, zinc, and copper and Iron levels in blood and liver function test (Bilirubin, Serum Glutamate Oxalate Transaminase, Serum Glutamate Pyruvate Transaminase, Akaline Phosphatse, Gamma Glutamyl transferase, Total Protein, Albumin, and Globulin) in 100 patients with liver cirrhosis and compared with 50 normal people without liver cirrhosis or any other clinical problems. Results__ampersandsignmdash; the values of serum GGT, Bilirubin, copper and Iron levels in blood were increased statistically significant (p__ampersandsignlt;0.00l) in liver cirrhosis when compared with the control subjects. Statistically significant difference (p__ampersandsignlt;0.00l) in selenium, zinc and Albumin were also found in subjects of liver cirrhosis. Conclusions__ampersandsignmdash;the correction of serum trace elements concentration would have a beneficial effect on treatment, complication and progression of the diseases, so it would be recommendable to provide laboratory analysis of trace elements as a routine in liver cirrhosis patients.