Introduction: The profunda femoris artery which is the largest deep branch of femoral artery provides the principal supply to the extensor, adductor and flexor muscles of the thigh. This large artery arises from the posterolateral side of the femoral artery about 3.5-5cm from the mid-inguinal point and gives lateral and medial circumflex femoral branches and three perforating branches. The study of the femoral artery and its branching pattern has been a great interest among the anatomists and the surgeons because of its major implication in the clinical as well as radiological interventions. Material and Methods: This artery is easily accessible to catheterization and thereby to investigation of any arterial system in the body. In the present study, twenty (40 limbs) formaldehyde embalmed cadavers without malformations were dissected during the educational dissection in the Department of Anatomy, Kasturba Medical College. Results: We got the results like higher origin of the profunda femoris artery was seen in one specimen, the descending branch of the circumflex femoral artery arising from the femoral artery, descending branch of lateral circumflex femoral artery arising as a separate trunk from the profunda femoris. MCFA arising from the femoral artery about 3.2cm proximal to the origin of profunda femoris, the ascending circumflex femoral artery from the profunda femoris artery. Taking into consideration about the importance of the femoral artery and the profunda femoris artery primary attention has been given for the accurate anatomical knowledge about the aforementioned vessels. Hence, this present cadaveric study has been undertaken to study the prevalence of origin of the profunda femoris artery along with its circumflex branches.