This study is to compare the efficacy of methylprednisolone, as a single 40mg dose and Dexamethasone, as a single 4mg dose injected into masseter muscle prior to placement of incisions. A prospective randomized study comprising 10 patients undergoing elective Bilateral Impacted lower third molar surgery with similar severity index were randomly assigned into Group I who received a single dose of methylprednisolone 40 mg injected into masseter muscle through intrabuccal approach and group II who received a single dose of Dexamethasone, as a single 4mg injected into masseter muscle through intrabuccal approach after Inferior alveolar nerve and long buccal nerve block. Steroidal Injections were given prior to the surgical removal of the impacted lower third molars. The inclusion criteria were: healthy patients aged over 18 years of either sex and without contraindication for corticosteroids. Ten patients were selected for the study. The mean age was 24 years (SD 5). Males were 56% than females 48%. The evaluation of postoperative pain, trismus, swelling and swallowing is made using the parameters: Interincisal distance to measure the mouth opening, assessment of swelling by measuring - tragus-lip commissure, Gonion-lip commissure and Gonion-outer canthus of the eye, preoperatively, second and seventh day postoperatively. Pain and swallowing assessed by using VAS on a 1-10 scales for every hour for six hours after surgery and during the next three days once in morning and night. No difference between the Methylprednisolone and Dexamethasone injected into the masseter muscle in surgical removal of impacted lower third molars.