Acute Myocardial Infarction (AMI) is an important health problem with poor outcome despite impressive advancement in diagnosis and management. Objective: The purpose of this study is to investigate the role of C-reactive protein (CRP), Malondialdehyde (MDA) and serum Uric Acid as a predictor of outcome in Acute Myocardial Infarction (AMI). Materials and Method: A study was conducted in 72 subjects; 42 patients with AMI (35 years to 81 years), of which 6 patients expired during the study (4 Males, 2 Females) and 30 age and sex matched healthy control. These subjects are divided into among 3 groups, Group I- 6 AMI patients who expired after 7th day, Group II -36 patients with AMI; and Group III- 30 control group. Serum CRP, Uric acid and MDA readings were taken on day 1, 3 and 7 from the onset of symptoms. Result: Group I and II readings are found statistically significant (p__ampersandsignlt;0.01) on all days as compared to the control (Group III). All the parameters in Group I showed an increasing trend and remained significantly elevated on day 1, 3 and 7 compared to Group II and controls. Conclusion: Our results suggest that inflammation and oxidative stress play important role in AMI and can be used in predicting outcome in AMI.