Aim: The aim of the systemic review is to emphasize the effect of contamination on bond strength of orthodontic light cure adhesives. Methods: The search was carried out by electronic database- Advance PubMed. The studies were selected if they met the following criteria: It should be In-Vitro study. Specimen used should be human or bovine teeth. Media used for contamination are saliva, blood or water. Orthodontic brackets or buttons bonded to the enamel surface of the teeth with orthodontic light cure adhesives by direct bonding technique. Results: Thirty articles were selected based on the inclusion criteria. Bond strength of different orthodontic primers and adhesives were recorded as variables of interest. Conclusion: It was concluded that contaminations affect the bond strength of orthodontic light cure adhesives.