This study work was carried out to investigate the pharmacological prooperties of __ampersandsignlsquo;Bacopa monnieri__ampersandsignrsquo;. This study reveals that the plant has antibacterial and antimutagenic activities. Thus an attempt was made to reinvestigate aforementioned antimicrobial as well as cytotoxic properties for the bark constituents. Bacopa monnieri (L.) Penn., (root bark and stem bark) have been intended to be accomplished in this study. Review of the biological activities of Bacopa monnieri (L.) Penn. The powdered plant was successively extracted with ether solvent. The antimicrobial investigation showed activity against four bacteria and one fungus.