Background: The regular use of contact lens for improving vision has seen an increasing trend worldwide and this can be attributed to increase in awareness through better advertisement, easy availability and handling, better products through advanced manufacturing strict guidelines. Our Objectives was to assess knowledge and compliance regarding contact lens wear and care among female college students in Saudi Arabia. Methods: A cross-sectional descriptive study was conducted from March to May, 2010, among randomly selected 50 female students of King Saud University, Riyadh, who were aged between 18 __ampersandsignndash; 25 years. Data were collected through pre-designed, pre-tested self- explained questionnaire with the help of optometrist. Results: It was found that significant number of the study population (88%) was regularly cleaning the lens case. However, only 58 percent of them cleaned their hands before putting the contact lens in the lens case while the remaining either did not clean at all (18%) or cleaned irregularly (24%). There were findings related to the habit of immersing the lens, only half the lens in the cleaning solution (34%). Regular visit to eye practitioners (38%) and use of contact lens beyond the expiry date (10%). Conclusion: It appears that primarily it is poor hand hygiene, inadequate care of the lens and the lens case, improper use of the cleaning solution and irregular follow up visits to the eye practitioners for eye check among the young female population.