Objective: Rate pressure product (RPP) is an indirect measure of Myocardial oxygen consumption (MVO2).It increases progressively with exercise and the RPP at peak of exercise is Peak rate pressure product (PRPP). The low value of PRPP suggests significant compromise of coronary perfusion. In the present study effect of exercise on RPP of Pre menopausal women and Post menopausal women were compared. Research Design and Methods: The study was conducted on a total of 50 healthy volunteer women. They were subjected to treadmill exercise test and baseline and maximum RPP was calculated. Results: The RPP in premenopausal women increased significantly from 10.83 __ampersandsignplusmn; 2.11 to 28.98 __ampersandsignplusmn; 2.93 mm of Hg beats / min x 10-3 during exercise and in postmenopausal from 12.52 __ampersandsignplusmn; 2.69 to 28.03 __ampersandsignplusmn; 4.14. The percentage increase in RPP was significantly more in Premenopausal women (63%) as compared to postmenopausal women (55%). Conclusions: It can be concluded that Rate pressure product reaches the critical value before the symptoms appear and the percentage increase in Rate pressure product was less in postmenopausal women. The results also suggest that the measurement of Peak rate pressure product in response to exercise can detect Coronary Artery Disease (CAD) even before the appearance of clinical signs and symptoms in postmenopausal women and thus can be used as a diagnostic tool.