There__ampersandsignrsquo;s a current interest in the economic conversion of renewable resources into industrially useful products. For this a large number of agriculture wastes have been harnessed.. Of this pineapple waste is one of them. The ability of different bacterial and yeast strains isolated from ripe pineapple peels waste to degrade cellulose from pineapple wastes was investigated by assessing cellulose decomposition by the method of cellulose Congo red agar media hydrolysis capacity (HC-value). Of the 8 isolates screened for their fermentation ability, 6 showed enhanced performance and were subsequently identified and assessed for cellulose degradation and amounts of glucose produced. Solid state fermentation was carried out in flasks containing pineapple peel waste and pulp wastes as substrates and inoculums of 10% size was cultured in a rotary shaker at a pH of 4.5 and at temperatures ranging from 220 C, 270C, 320C and 350C for 21 days. Cellulose degradation and amounts of glucose produced by 4 test organisms and 1 positive organism in both peel and pulp of pineapple was determined. The highest amount of cellulose degradation and glucose formation was produced by the bacterial isolate PPP04 for peel waste and the yeast isolate YP02 for pulp waste. The present study was undertaken to identify bacteria and yeasts which could degrade cellulose and that which could be used for their degrading ability for commercial production of ethanol and vinegar.