Background: Diabetes Mellitus (DM) is the most common disorder characterized by metabolic abnormalities and long term complications. Patients with type 2 diabetes mellitus are more prone to Coronary Artery Disease (CAD). Although oxygen free radicals are known to contribute to the development of CAD and diabetes. Oxidative stress occurs as a result of increased level of lipid peroxides and free radical intermediates, as well as the decreased in total antioxidant capacity. Aim: In the present study, our aim was to investigate the lipid peroxidation, lipid profile and antioxidant enzymes in diabetic patients with and without CAD. Materials and Methods: The study was carried out in 62 patients suffering from diabetics, 59 patients suffering from diabetes with CAD and 78 healthy controls were randomly selected. Various parameters like serum lipid profile, Malondialdehyde used as an index of oxidative stress, antioxidant enzymes like Glutathione peroxidase (GPx), Superoxide dismutase (SOD), and Paraoxonase (PON) were measured and compared. Results: Increased levels of MDA concentration, total cholesterol, triglycerides, LDL-cholesterol, while decreased levels of HDL- cholesterol, GPx, SOD and PON were significantly low (p