Introduction: Acute pancreatitis is an inflammation of the pancreas caused by auto-digestion of the gland by its enzymes. It includes a broad spectrum of pancreatic diseases, which vary from parenchymal edema to necrosis. The objective of the current study was to describe the symptoms of the patients with gallstones-associated pancreatitis and to reinforce the opinion that operation, within the first 72 hours after the onset of the disease, has many advantages and has to be considered as a treatment option when Endoscopic Retrograde CholecystoPancreatography (ERCP) is not available. Methods: The present retrospective study concerns all patients that were hospitalized in Civil Hospital, Sangli during the period between Jan 1, 2001 and Dec 31, 2011 under the diagnosis of gallstone-associated acute pancreatitis. From the records 216 cases were identified (86 males and 130 females). The mean age was 62.93 (SD 15.85years), ranging from 17 to 91 years. Results: 48 patients (22.22%) fulfilled more than 3 of Ranson__ampersandsign#39;s criteria. 40 patients (18.52%) presented with necrotizing pancreatitis. All patients underwent open cholecystectomy and common bile duct exploration. Necrosectomy concomitantly with cholecystectomy was performed in 14 patients (6.48%). The mean hospitalization was 10.53 days (S.D. 6.38 days), ranging from 2 to 36 days. The associated mortality reached 5.55% (12 patients) and no patient died in the operating theatre. During the 12-month follow-up period, 4 patients (1.85%) developed pancreatic pseudocysts.