Introduction: Effect of stress on cardiovascular hemodynamics has been addressed in several studies. Epidemiological evidence suggests that there is relationship between stress and cardiac morbidity and mortality in susceptible individuals. Present study was conducted to study the effect of physical and mental stress on various cardiovascular parameters in healthy adults. Methods: The present study comprised of 90 healthy male subjects who underwent thorough clinical examination to rule out cardiovascular diseases. The subjects were exposed to various stressors like 3 minute mental arithmetic calculations, Harward step test, and cold pressor test. Various ECG derived indices like QT interval, Corrected QT interval and QT dispersion were studied before and after inducing stressors. Results: Statistically significant increase in heart rate, blood pressure and decrease in QT interval (P__ampersandsignlt;0.05) was observed but increase in QT dispersion was not statistically significant (P__ampersandsigngt;0.05). Interpretation and conclusion: Prolonged QT dispersion during different stressors is regarded as a marker of imbalanced distribution of sympathetic nervous system on heart. Despite this known fact QT dispersion is not affected in our subjects strongly emphasizing that prolonged QT dispersion is always associated with cardiac pathology. It was concluded that altered cardiac functions have direct effect on sympathovagal imbalance leading to increase in QT dispersion.