Background: Taping has been successfully used by physiotherapists in management of sports injuries. It has been proposed that it can be used to treat degenerative joint disease like osteoarthritis however there is a lack of evidence. Purpose: To compare the effectiveness of taping technique along with conventional physical therapy versus conventional physical therapy alone in patients with patellofemoral joint osteoarthritis. Methods: Thirty subjects with mean (SD) age of 55__ampersandsignplusmn;6 years were randomized into 2 groups. Subjects in group A were treated with McConnell taping technique along with ultrasound therapy and supervised exercise protocol while subjects in group B were treated with ultrasound therapy and supervised exercise protocol. The outcome measures were Visual Analogue Scale (VAS); Western Ontario McMaster Universities index (WOMAC), Timed Up and Go test (TUG) and Timed Stair Ambulation Test (TSAT) which were assessed prior and after 2 weeks of intervention. Results: Both the groups showed significant improvement in pain scores. Between groups comparison found that group A displayed statistically significant improvement in terms of pain intensity, WOMAC score, TUG and TSAT. Conclusion: Patients in taping group had greater gains in attaining functional abilities and pain relief compared to conventional group, though there was no significant difference in improvement in timed stair ambulation test between the two groups. Therefore, application of taping can be considered beneficial for pain relief and functional ability improvement in subjects with patellofemoral joint osteoarthritis.