Background of the Study: In humans, lead can cause a wide range of biological effects depending upon the level and duration of exposure. The heavy metal lead (Pb) is one of the most widely scattered toxic metals in the world. It has been used by mankind for over 9000 years. Lead in the environment may be derived from natural or anthropogenic sources. Aim and Objective: The aim of this study was to investigate the adverse effect of exposure to lead on a) systolic and diastolic blood pressure, b) serum calcium, ionized calcium, phosphorus and c) kidney functions, of automobile workers. Methods: For this study, two groups of thirty (30) automobile workers and thirty age matched healthy control subjects were selected from Bijapur city. Demographic, occupational and clinical data was collected using questionnaire. From these two groups, venous blood samples in EDTA and Plain bulbs and random midstream urine samples were collected in amber coloured bottles. The biochemical parameters were estimated using standard assay procedures. Statistical analysis of the data was done using independent student?s__ampersandsignbdquo;t? test for parametric variables. Values were expressed as mean __ampersandsignplusmn; standard deviation (SD). P values of 0.05 or less were considered to be statistically significant. Results and Conclusions: As compared to controls, the automobile workers were found to have significantly increased (P__ampersandsignlt;0.001) blood and urinary lead levels, significantly increased (P__ampersandsignlt;0.05) systolic and diastolic blood pressure and high (P__ampersandsignlt;0.05) levels of blood urea, serum uric acid and serum creatinine levels and the levels of serum calcium, ionized calcium, phosphorus were significantly reduced (P__ampersandsignlt;0.001). The chromatography of the urine samples shows the generalized aminoaciduria in these workers. The results of this study clearly indicate that the absorption of lead is more in these workers which adversely affects blood pressure, disturbs calcium and phosphorus metabolism and damages renal tubules. Since absorption of lead has ill effects on the health of automobile workers, there is an urgent need to safeguard them from the hazards of occupational lead exposure.