During routine dissection, of the right upper limb of a 70 years old donated embalmed male cadaver in the Department of Anatomy, K.J. Somaiya Medical College, Sion, Mumbai, India, we observed the variant nerve supply to Extensor carpi radialis brevis muscle. In the present case the nerve supply to extensor carpi radialis brevis was from the superficial branch of radial nerve i.e. the radial nerve proper. The finding was noted after thorough and meticulous dissection of the upper limbs of both sides. The arterial pattern of upper limb were also observed. The variation was unilateral. The left upper limb was normal. The photographs of the variations were taken for proper documentation. Conclusions: The awareness of the nerve supply to extensor carpi radialis brevis from superficial branch of radial nerve is clinically important for surgeons dealing with entrapment or compressive neuropathies, orthopaedicians operating on the fractures of the lower end of the humerus, anaesthetist performing pain management therapies on the upper limb and physiotherapist doing electromyography for evaluating and recording the electrical activity produced by skeletal muscles. A lack of knowledge of such type of variations might complicate surgical repair.