Aims: Cinnamon seems to be highly bioactive compound, appearing to mimic the effect of insulin through increased glucose uptake in peripheral tissues. The present study was planned to explore the potential antidiabetic, serum insulin and insulin sensitivity properties of cinnamon bark and compare its effects with antidiabetic agents in diabetic rabbit model. Methods and Material: Diabetes was induced in rabbits using alloxan (90mg/kg IV). Four groups (n=6 each) received suspensions of cinnamon (150mg / kg OD orally), glyburide (0.35 mg /kg orally), metformin (35mg/kg BD orally) or vehicle (6 ml of 5% gum tragacanth). Blood samples were collected weekly thereafter for five weeks to measure fasting blood glucose level, s. insulin level, HOMA-IR index. Results: Administration of cinnamon powder reduced blood glucose level and elevated serum insulin in diabetic rabbits over a period of 5 weeks. Results for HOMA __ampersandsignndash;IR are inconsistent in this study. Conclusions: Our results suggest that cinnamon extract significantly improved hyperglycemia and potentiate insulin level in diabetic rabbit model but its role on insulin sensitizing property still remains unclear.