The study describes the infection of the acanthocephalan, Neoechinorhynchus agilis sp. The (grey mullet) Mugil cephalus is highly valued food along the Corentyne coast, Berbice, Guyana. The fish Mugil cephalus were collected from Bush Lot, Whim, 43 Village 63 Beach and 79 Village, Corentyne coast. The infections with the parasites were observed in posterior region of the intestine, liver and muscle, almost blocking the lumen during the examination of M. cephalus. At thee site of the parasite attachment, the surface of the intestine appeared thickened along the mucosal epithelium. A description of the parasites and its clinicopathology is discussed. Though the worm substantially damaged the architecture of the intestinal tissues, no apparent ill effects on the general health condition of the fish were observed. This is the first report of Mugil cephalus of Berbice River, Corentyne coast from Guyana.