A huge number of cases of morbidity and mortality worldwide are attributed to Adverse Drug Reactions (ADRs), therefore this study was done with the primary Objective of assessing the Knowledge regarding pharmacovigilance and to evaluate the impact of an educational intervention on the same among healthcare professionals in a tertiary care centre. Methods: A questionnaire containing 20 questions was given to all the participants before the educational session. Later, an interactive educational session on pharmacovigilance was conducted for them. After the educational session, the same questionnaire was given to all participants. The impact of effectiveness of educational session among health care professionals was evaluated by statistical analysis. 80 health care professionals were involved in the study. 37 Post Graduates of different departments, Assistant Professors 14, senior residents 10, Associate Professors 15, and 4 Professors were participants of this study. Results: The overall response rates during pre intervention was 23.48%, which significantly increased to 25.99% during post intervention (P value __ampersandsignlt;0.0001). 80% of the health care professionals admitted that awareness amongst healthcare providers would help to improve the pharmacovigilance programme. Conclusion: Educational session in this study has shown significant improvement in the awareness about pharmacovigilance among health care professionals.