Objective: To evaluate the antidepressant activity of statins in mice. Methods: Sixty adult Swiss albino mice weighing 25-30 grams were selected. Thirty were allocated to forced swim test and thirty to tail suspension test models. In each model there were 5 groups. The control group received vehicle (10 ml/kg, p.o), the standard, Imipramine (10 mg/kg, p.o) and the three test groups received atorvastatin, simvastatin and rosuvastatin respectively, 1hour prior to the acute study. In chronic study the drugs were given orally once a day for 10 days and the last dose was given 1hour before the experiment. Duration of immobility was noted in forced swim test and tail suspension test. Statistical analysis was performed using Mean +/- SEM. ANOVA followed by Dunnett__ampersandsignrsquo;s test. P__ampersandsignlt;0.05 was considered statistically significant. Results: Statins produced significant antidepressant effect at all the doses, as indicated by reduction in the duration of immobility compared to the standard. The antidepressant effect was higher with atorvastatin when compared to simvastatin and rosuvastatin. Conclusion: Statins has shown significant antidepressant activity greater than imipramine in mice.