Fever in infancy can imply a wide spectrum of illnesses that range from an innocuous upper respiratory infection to life threatening systemic infection. Hence fever without a focus in an infant has been, is and will be a diagnostic dilemma for the paediatrician. Here we present a case who presented similarly with fever without focus, however the cause finally elucidated was the rare Caffey__ampersandsignrsquo;s disease. Caffey__ampersandsignrsquo;s disease is a rare disorder whose etiology is yet to be clearly elucidated. It is characterised by cortical hyperostosis with inflammation of adjacent fascia and at times the overlying muscle is also involved. It most often presents in infancy with sudden irritability, soft tissue swelling visible over the involved bones having a woody induration with no suppuration, fever and anorexia. The disease is also known to have an unpredictable course with remissions and relapses. A high index of suspicion with a good radiology and laboratory backup is thus necessary to make a diagnosis and plan treatment.