Purpose of Study: This study envisages highlighting the main ailments for which college students use self-medication and to compare and contrast significant differences in the pattern of drug use between two study groups- Undergraduate Medical and Non-Medical students of the city of Udaipur, India Methods: Self-administered, pretested, close-ended, semi-structured questionnaire was used to collect data, and to analyze the pattern from 320 Medical and 320 Non-Medical students. Results: More Non-Medical (30%) students used media as their source of information (p__ampersandsignlt;0.001).Intake of pain-killers, antibiotics, antiseptics, drugs for nausea, vomiting, fever, constipation and diarrhea, was higher in Medical students(p__ampersandsignlt;0.001) while intake of drugs for weight reduction, anxiety, hormonal preparation and steroids was higher in Non Medical students(p__ampersandsignlt;0.001). 95% Medical and 83% NonMedical students were aware of adverse drug reactions. 90% of Non-Medical students used advertised drugs. Conclusions: Medical students were less likely to self-medicate drugs that carried more risk of adverse reactions. There was greater media influence on the choice of drugs by Non-Medical students.