Hexachlorobenzene (HCB) is one of the highly toxic and persistent compounds that are released unintentionally through various man-made chemicals. It is considered as a member of POPs (persistent organic pollutants) because it is persistent for long period of time in the environment and found to be hazardous for all living organisms. The present review focuses on the various sources of hexachlorobenzene present in the environment. Few Remediation technologies currently available for destruction of HCB from the environmental compartment such as soils, sediment and air were described in detail. Further, the transfer of HCB in to environment, their mode of action, toxicity, exposure and its health effects were also discussed.