Hashimoto__ampersandsignrsquo;s thyroiditis(HT) is a chronic autoimmune thyroiditis affecting women more commonly. It is characterized by lymphoplasmacytic infiltration of thyroid follicular cells, hurthle cells resulting in atrophy of the follicular cells and fibrosis. Cystic change is an unusual finding in Hashimoto__ampersandsignrsquo;s thyroiditis. A 35 year old female presented as nodular goiter clinically with ultrasound showing multiple cystic areas. Histopathological examination of the specimen after thyroidectomy showed features of Hashimoto__ampersandsignrsquo;s thyroiditis with cystic areas. We report a rare case of Hashimoto__ampersandsignrsquo;s thyroiditis with cystic changes in for the first time to the best of our knowledge. A more detailed study in this regard is warranted to understand the pathogenesis of cystic changes in HT.