Nowadays doping is critical issue at International level in sport Physiology. This is not only concerned with health matter but also with the moral as well as ethical values of humanity affecting honest team spirit of sports competition. This is directly affecting sports, competitions around the world. Blood doping is the misuse of specific substances to increase one__ampersandsign#39;s red blood cell mass, which allows the body to transport more oxygen to muscles and therefore increase performance and stamina of player or person. There are seen a list numbers of life threatening side effects occurred as a result of blood doping like increases in blood viscosity, myocardial infarction, embolism, stroke, infections, allergic reactions and certain risk of blood born disease like HIV,Hepatitis etc. Anti-doping policies instituted by individual sporting governing bodies may conflict with local laws. There is no such correlation between these authorities and government laws. Nowadays there are a numbers of techniques as well as drugs are using by players, which is really a challenge to detect them by experts and fight the war against doping. However it is our responsibility to fight against them, with update of knowledge and events.