Objective: To evaluate the different liver space occupying lesions diagnosed on FNAC presenting at our hospital and share our experience of Fine Needle Aspiration Cytology of liver lesions. Material and Method: Retrospective study of total of 400 cases of liver space occupying lesions was done at Gujarat Cancer and Research Institute, Ahmedabad during 6 months period (January 2015 to June 2015). Papanicolau (PAP) and May-Grunwald-Giemsa (MGG) stained smears were reviewed and analyzed. Inconclusive aspirations and inadequate aspirations were excluded from study. Results: 294 cases out of 400 cases - where FNA yielded adequate cellularity were analyzed. Age ranged from 1 to 80 years with male predominance. Out of 294 cases, 292 cases (99.32%) were diagnosed as neoplastic and 2 cases (0.68%) as non neoplastic lesions. Of total 292 cases, 66 cases (22.44%) were diagnosed as primary hepatic malignancies in which 7 cases (2.37%) were of Hepatoblastoma and 59 cases (20.07%) of Hepatocellular carcinoma. Metastatic tumor was the most common and constituted 226 cases (76.88%). Metastatic lesions were Adenocarcinoma (62.93%), Small cell carcinoma (7.15%), Squamous cell carcinoma (1.36%), Malignant Melanoma (1.36%), Neuroendocrine tumor (1.70%) and Medullary carcinoma (0.34%) in decreasing order of frequency. The two non neoplastic lesions were of Abscess formation (0.68%). Conclusion: Cytology is a first line of investigation in liver space occupying lesions as the procedure is minimally invasive, safe, simple, quick and cost effective.