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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="healthcare" lang="en"><front><journal-meta><journal-id journal-id-type="publisher">IJCRR</journal-id><journal-id journal-id-type="nlm-ta">I Journ Cur Res Re</journal-id><journal-title-group><journal-title>International Journal of Current Research and Review</journal-title><abbrev-journal-title abbrev-type="pubmed">I Journ Cur Res Re</abbrev-journal-title></journal-title-group><issn pub-type="ppub">2231-2196</issn><issn pub-type="opub">0975-5241</issn><publisher><publisher-name>Radiance Research Academy</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1274</article-id><article-id pub-id-type="doi"/><article-id pub-id-type="doi-url">http://dx.doi.org/10.7324/IJCRR.2017.9128</article-id><article-categories><subj-group subj-group-type="heading"><subject>Healthcare</subject></subj-group></article-categories><title-group><article-title>To Mask the Bitter Taste of Rizatriptan Benzoate and Develop Water Dispersible Tablets&#13;
</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>C.</surname><given-names>Chilate Vikrant</given-names></name></contrib><contrib contrib-type="author"><name><surname>D.</surname><given-names>Godbole Mangesh</given-names></name></contrib><contrib contrib-type="author"><name><surname>V.</surname><given-names>Sonaye Harsha</given-names></name></contrib><contrib contrib-type="author"><name><surname>C.A.</surname><given-names>Doifode</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><day>24</day><month>06</month><year>2017</year></pub-date><volume>)</volume><issue/><fpage>39</fpage><lpage>48</lpage><permissions><copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement><copyright-year>2009</copyright-year><license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p></license></permissions><abstract><p>Introduction: Rizatriptan benzoate is anti migraine drug. Report indicates that, it has very bitter taste, which deters its use in geriatrics patient thus not comply with prescription that results in high incidence of non-compliance and ineffective therapy.&#13;
Aim: To mask the bitter taste of Rizatriptan benzoate and develop water dispersible tablets.&#13;
Methodology: The sweetener like aspartame was use in variable ratio with drug. Physical mixture of Rizatriptan benzoate with Aspartame (1:5 ratio) were rated most effective (0.4) by the panel of tastes. The other used sweeteners did not prove to be very effective for masking of bitter taste as indicated by the high rating of bitterness score 2-3 and 3-4 by panel of human tastes. Water dispersible tablets of Rizatriptan benzoate was formulated by direct compression method using physical mixture of drug: aspartame with superdisintegrants viz. sodium starch glycolate, croscarmilose sodium and crospovidone in variable ratios.&#13;
Result: All the formulation batches passed the weight variation test, disintegration test and uniformity of dispersion test and offered good mechanical strength.&#13;
Discussion: The combination of sodium starch glycolate with crospovidone in the ratio of 1:2 given best result (disintegration time 19.18 sec), the disintegration time was decreased from 32 to 19 sec.&#13;
Conclusion: All formulation batches released more than 98% of drug within 30 min.&#13;
</p></abstract><kwd-group><kwd>Water dispersible tablet</kwd><kwd> Rizatriptan benzoate</kwd><kwd> Aspartame</kwd><kwd> Sodium starch glycolate</kwd><kwd> Cross povidone</kwd><kwd> Sodium carboxymethyl cellulose</kwd><kwd> Magnesium stearate</kwd><kwd> Aerosil</kwd></kwd-group></article-meta></front></article>
