Topiramate, a commonly used drug in the management of seizures and migraine headache, can increase the risk of calcium phosphate kidney stones. However, specific side effects are nausea, anorexia, parasthesia, memory problems etc. We report a case of 54 year old male patient with alcohol withdrawal syndrome treated with bupropion, disulfiram, topiramate, chlordiazepoxide. After one year of treatment, the patient developed nephrolithiasisand rhinolith on right side which was confirmed by USG and CT scan respectively. As all other drugs except topiramate do not have any tendency to form stones, the most probable drug may be topiramate. ENT specialists should be aware of this possible complication to undertake early interventions.