Loss of taste sensation is often noted in majority of CNS lesions, but this has not been given much importance by the medical community. The taste pathway as described in standard physiology textbooks do not support the available evidence on the loss of taste sensation in central lesions. Taste disorders related to central lesions can either be ipsilateral, contralateral or bilateral according to area of injury of the taste pathways. However, some questions remain, particularly regarding the exact crossing site of human gustatory afferents. In the present review an attempt is made to unveil the taste pathway based on clinical data available. Loss of taste sensations in relation to lesions in medulla, pons, midbrain and thalamus have been highlighted.