Introduction: Needle stick injury is an underestimated problem among health care personnel all over the world.More than 20 types of blood borne pathogens especially Hepatitis B virus, Hepatitis C virus and Human immune deficiency (HIV) virus can be transmitted through needle stick injuries. Aim of Study: The main aim of our study was to assess awareness regarding needle stick injuries with risk of serious infections and awareness regarding first aid and post exposure prophylaxis. Material andMethods: Data was collected in the form of pre-tested self-administered questionnaire. 100 students participated in the study. The response to questionnaire was analysed and results were obtained. Results: The incidence of needle stick injury among students was found to be 24%.47% of students were not aware of recommended first aid after needle or sharp injury.Regarding Hepatitis B vaccination, 65% were not vaccinated, only 35% were vaccinated. 94% of students had never received any training regarding sharps. Conclusion: This study showed a high rate of needle stick injuries among interns and post graduate students. Still the incidence is on lower side, owing to non-reporting of injuries. The strong predictor for needle stick injury was lack of training and work load. Recapping of needles was found to be the most common reason for needle stick injuries.