Coronary Artery Disease (CAD) leads to Angina and Myocardial Infarction (MI). Premature mortality on Coronary Heart Disease (CHD) is more common in diabetic atherosclerosis. In the present study serum Uric Acid level was estimated in patients of CAD with DM, CAD without DM, DM without CAD and CAD with DM and other risk factors compared to healthy normal subjects. The level of Uric Acid was significantly increased in all four groups of patients as compared to control group. Conclusion: On the basis of our results we conclude that high circulating uric acid levels may be indicator that the body is trying to protect itself from harmful effects of free radicals by increasing the production of endogenous antioxidants like uric acid. Hence uric acid may act as non conventional marker to predict the risk of Coronary Vascular Disease (CVD) complication in Diabetes Mellitus (DM).