Hypoparathyroidism is one of the rare endocrinopathy in __ampersandsignbeta; thalassemic patients as a consequence of iron overload. Hypogonadotropic hypogonadism, hypothyroidism are still prevelant in __ampersandsignbeta; thalassemic patients inspite of intensive chelation therapy. Though regular blood transfusion may increase the life expectancy, yet growth disturbances and growth hormone defects in these children may be noticed. We present a rare case of multiple endocrinological defects following splenectomy in a known case of __ampersandsignbeta; thalassemia noted during biochemical investigations. The literature regarding the prevalence of hypoparathyroidism has been reviewed. Moreover, literature survey depicts that serum concentration of ferritin does not predict the occurrence of hypoparathyroidism, thus the case being reported.