Aim: Dementia is a chronic and progressive neurodegenerative disorder resulting in impairment of cognition and behaviour. Caring for person with dementia results in significant stress and this study aims to assess the quality of life of caregivers of patients suffering from dementia and the factors associated with it in the semi urban South Indian population Methodology: This study was conducted in the outpatient of the department of Psychiatry at a tertiary care hospital in south India. Persons over the age of sixty years meeting the diagnosis of dementia according to ICD 10 criteria along with the carers who were staying with them for at least a year were included in the study. Quality of life of the care givers which is the primary outcome measure of this study was assessed using the WHOQOL BREF version. Results: Half of the caregivers included in the study had poor quality of life. Some of the factors that predict poor quality of life among the caregivers are being unmarried or widowed, having comorbid physical illness, presence of behavioural and psychological symptoms in patients with dementia. Discussion: The results emphasize the importance of caring the caregivers and the management should be considered as a unit and treatment should not only focus on the patients but also on their caregivers. Conclusion: The findings of our study suggest that the caregivers of the persons suffering from dementia have poor quality of life. Female caregivers, elderly caregivers and with history of comorbid illness, the caregivers of dementia patients with behavioural and psychological symptoms have poor quality of life.