An attempt has been made to investigate the predictive analysis of desulphurization of as received iron ore using acetic acid. The investigation is based on as beneficiated iron ore content and input concentration of acetic acid. A solution of acetic acid was used for leaching the iron oxide ore and the reaction vessel containing the solution and ore was maintained at a temperature of 300C for 10 minutes. A model was derived and used as a tool for the analysis. The validity of the two-factorial model: __ampersandsigngamma; = 0.6235 __ampersandsignbeta;3 __ampersandsignndash; 1.1661 __ampersandsignbeta;2 + 0.5327__ampersandsignbeta; + __ampersandsigntheta;2 __ampersandsignndash; 0.081__ampersandsigntheta; + 0.0005 Was rooted on the expression __ampersandsigngamma; + 0.081__ampersandsigntheta; - 0.0005 = 0.6235 __ampersandsignbeta;3 __ampersandsignndash; 1.1661 __ampersandsignbeta;2 + 0.5327__ampersandsignbeta; + __ampersandsigntheta;2 where both sides of the expression are correspondingly approximately equal. Statistical analysis of the results of removed sulphur from derived model and experiment for each value of the input concentration of acetic acid shows standard errors of 0.034 and 0.04% respectively. Removed sulphur per unit input concentration of acetic acid as obtained from derived model-predicted and experimental results are 0.0079 and 0.0085 %/M. The maximum deviation of the model-predicted concentration of removed sulphur iron is less than 24%, implying an operational confidence level above 76%. It is inferred that desulphurization of the iron ore is feasible under the prevailing conditions of the experiment and model analysis.