Background: During the past few years, there has been an increase in public concern about the management of health care waste on a global basis. Due to public awareness and litigations, health care Waste collection and proper disposal have become a social issue in India. Objectives: The objective of the study is to analyze the implication of Project on Up gradation of Safety in Health care (PUSH) in health care waste management among government sector in TamilNadu. Methods: The amount of health care waste generated and the expenditure incurred among government sector from primary care level to tertiary care in Tamilnadu were studied. The study period was from 2009-10 to 2011-12.It is a cross sectional study. Results: There was a reduction of biomedical waste generated from 2009-10 to 2011-12. There was a reduction of health expenditures to CTF operators from 2009-10 to 2011-12. Conclusion: It was found that there was reduction of biomedical wastes generated and the reduction of expenditure to CTF operators due to Project on Up gradation of Safety in Health care (PUSH) in health care waste management among government sector in TamilNadu and this type of project can be followed in other part of India.